LIQUISOLID COMPACTS PDF

Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.

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The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate.

Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers

The liquid medication is the water insoluble drugs carried in suitable non-volatile solvents. Among the newly developed drugs which are meant for oral administration, around half exhibit solubility problem in water, which affects the formulation development process.

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At higher values the greater amount of carrier may overcome to some extent the flow compacfs of powder. Olmesartan appears to be more soluble in Acrysol EL than other vehicles.

DSC thermograms liqyisolid pure drug olmesartan, and powder mixture for optimized liquisolid preparations were obtained. The solubility of several therapeutic agents is an important technical challenge in formulating as a suitable dosage form efficient its drug delivery [ 12 ].

View at Google Scholar. Olmesartan dose dependently reduces the blood pressure through arterial vasodilation and reduced sodium retention, as do other angiotensin receptor blockers [ 8 ]. IntJ Pharm PharmSci 2: Olmesartan medoxomil is a novel selective angiotensin II receptor blocker that is approved for treatment of hypertension [ 6 ]. The liquisolid technology is described by Spireas as liquid may be transformed into a free-flowing, readily compressible, and apparently dry powder by simple physical blending with selected excipients named the carrier and coating material Figure 1.

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The maximum liquid load on the carrier material is termed as liquisoljd liquid load factor Lf. Visit for more related articles at Journal of Compscts. The flow property obtained by Neusilin was good and remains unaffected at such low amount. December 19, Accepted: The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients.

Introduction As a most discussed but still not completely resolved issue, solubility or dissolution enhancement techniques ccompacts the most vibrant compadts for the researchers in formulation science.

International Journal of Pharmaceutics Six tablets from each formulation were tested for hardness.

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However, this technique cannot be applied to high dose poorly soluble drugs is because of the high amount of liquid vehicle needed.

The flowable liquid retention potential was calculated using the following equation: The pronounced effect of the different carriers was not observed on dissolution profile so the flow properties and tensile strength were considered for optimizing the carrier.

A lesser amount of Neusilin was required to adsorb the same amount of liquid vehicle than Avicel and Fujicalin, which lowered the weight of tablet. Liquisolid compacts were prepared using Acrysol El as a solvent, Avicel PHFujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. Dissolution parameters of optimized liquisolid compacts and conventional tablets of Olmesartan medoxomil.

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The highest liquid factor was obtained for Neusilin, and accordingly, the amount of carrier was lower than other formulations. The was then used to decide the optimum amount of carrier and coating materials required to ensure dry-looking, free-flowing and compactible powdered systems.

To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below. The drugs belongs to the biopharmaceutical classification system BCS class II and IV shows very poor dissolution leads to incomplete drug release from the formulation, increased dose, large inter and intra-subject plasma concentration variation under both fed and fasted states eventually leads to poor bioavailability [ 34 ].

Formulation containing Neusilin-Neusilin and Neusilin- Aerosil showed no disintegration while all other formulations showed disintegration up to seconds. Aerosil is known to be hydrophobic in nature, which retards the flow properties. The excipient and coating material are to be taken into definite ratios so as to retain the accepted amount of liquid to liquisollid converted into solid.

Agri and Aquaculture Journals Dr. Solubility of olmesartan medoxomil was determined in various nonvolatile solvents.

Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil

Usually, microcrystalline cellulose and colloidal silica are used as the carrier and the coating material, respectively. Journal of Pharmaceutical Scienceand Research 3: Acrysol EL proved to be promising liquid vehicle for formulation of liquisolid preparations.

Thus, tablet weights are reduced in case of Fujicalin and Neusilin in comparison to commonly used carrier materials like Avicel.