LIQUISOLID COMPACTS PDF

Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.

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To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below. View at Google Scholar I. Five tablets from each formulation were tested for the disintegration time calculations. International Journal of ChemTech Research 2: Hence, the liquisolid technology allows the conversion of liquid systems into solid drug delivery systems such as tablets.

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement

The weight of luquisolid containing Neusilin and Fujicalin ranged in between fompacts. The solubility of several therapeutic agents is an important technical challenge in formulating as a suitable dosage form efficient its drug delivery [ 12 ]. Patil J Liquisolid Compact Technique: On the other hand, if a solid water-insoluble drug is formulated, it should be initially dissolved or suspended in suitable nonvolatile solvent system to produce drug solution or drug suspension of desired concentration.

The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Results of hardness, friability, and disintegration time are represented in Table 4. Spireas S, Sadu S Enhancement of prednisolone dissolution properties using liquisolid compacts. Formulation containing Neusilin-Neusilin and Neusilin- Aerosil showed no disintegration while all other formulations showed disintegration up to seconds.

Solubility of CBZ was determined in different non volatile solvents to finalise vehicle having maximum solubility.

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Thus, tablet weights are reduced in case of Fujicalin and Neusilin in comparison to commonly used carrier materials like Avicel. Formulations containing showed good flowability than formulations liquuisolid. DSC thermograms of pure drug olmesartan, and powder mixture for optimized liquisolid preparations were obtained. Several techniques have been reported to improve drug solubility, among which the liquisolid technology is one of the most promising approaches.

The solubility of CBZ in polyethylene glycol was found to be greater than the other solvents. Acrysol EL proved to be promising liquid vehicle dompacts formulation of liquisolid preparations. Olmesartan medoxomil is a novel selective angiotensin II receptor blocker that is approved for treatment of hypertension [ 6 ]. It is a prodrug rapidly co,pacts during absorption from the gastrointestinal tract to produce an active metabolite, olmesartan [ 7 ].

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International

It can be concluded from this study that novel porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose drugs like CBZ.

Ann Jose ankara escort. Characteristic peaks of the individual excipients were also retained; also no new peak was found in drug-loaded mixture of the excipients to be formulated in liquisolids.

The several mechanisms by which solubility enhancement takes place have been postulated for liquisolid systems. Solubility of olmesartan medoxomil was determined in various nonvolatile solvents.

Another measure of tablets strength is friability. The poor dissolution rate of water-insoluble drugs is still compacta major problem confronting the pharmaceutical industry.

Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil

Fujicalin and Neusilin are used as carrier materials instead of Avicel, the liquid adsorption capacity increases liquisolif many folds. International Journal of Pharmaceutics Figures 3 a and 3 b show the thermogram for olmesartan medoxomil and liquisolid mixture.

Agri and Aquaculture Journals Dr. In the formulation development process solubility of active compound is one of the main criteria considered before deciding the dosage form. December 20, Published: Withdrawn samples were filtered through a 0. Due to significantly increased wetting properties and surface area of the drug particles available for dissolution, liquisolid tablets were expected to enhance drug release characteristics and, consequently, improved oral bioavailability.

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Indexed in Web of Science. A Novel Approach to Solubility Enhancement. The liquid medication is the water insoluble drugs carried in suitable non-volatile solvents.

Permissions beyond the scope of this license may be available with editor ijper. The less drug concentration in the vehicle means more fraction of the drug is liable to be in the liquid solution form i. Formulated liquisolid compacts showed all physical parameters within prescribed limit. Fujicalin Dibasic calcium phosphate anhydrous and Neusilin Magnesium aluminometasilicate were obtained as compactd sample from Fuji Chemical Industry Co.

Journal of Pharmaceutical Scienceand Research 3: The and for liquid vehicles were used to calculate. Spireas S Liquisolid systems and methods of preparing same. The maximum liquid load on the carrier material liqiusolid termed as the liquid load factor Lf.

Concentration of dissolved drug was determined using standard equation. The aim of present investigation was to prepare liquisolid compacts of high dose water insoluble drug, carbamazepine CBZ using novel porous carriers such as Neusilin comoacts Fujicalin in order to improve its dissolution rate and reduce the tablet weight.

To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of liquisolid systems has been developed by Spireas [ 78 ].

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