Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous . Lúpus eritematoso sistêmico bolhoso – diagnóstico diferencial com dermatite herpetiforme. O lúpus eritematoso sistêmico pode apresentar inúmeras lesões cutâneas. As lesões bolhosas específi cas do lúpus, apesar de raras, apresentam. Systemic lupus erythematosus (SLE) can cause numerous skin lesions. Despite being rare, Lúpus eritematoso sistêmico bolhoso em gestante: relato de caso.

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It is important to remember that in both EBA and BSLE, anti-type VII collagen antibodies are nolhoso in the sublamina densa of the basement membrane zone and that both conditions have similar genetic characteristics as they are both associated with the HLA-DR2 antigen. Sapadin AN, Fleischmajer R. Nelise Ritter Hans-Bittner 1 Dr.

Histopathological examination reveals a subepidermal blister with neutrophilic microabscesses in the dermal papillae, perivascular inflammatory infiltrate composed of lymphomononuclear cells and, in some cases, leukocytoclastic vasculitis. Colchicine is a therapeutic option for neutrophil-mediated bullous diseases.

Autoimmune Diseases

A year-old female patient was admitted with a complaint of tense vesiculobullous lesions, both isolated and in clusters, on her face, neck, torso and oral and genital mucosae on circinate and erythematous edematous plaques Lupue 1234.


Pathological examination suggested dermatitis herpetiformis, and direct immunofluorescence revealed IgG, IgA and fibrin in the epithelial basement membrane zone.

There was complete remission with dapsone, with no recurrence of skin lesions throughout one year of follow-up. Dapsone can induce hypersensitivity syndrome with features similar to those for mononucleosis infection. Histopathological examination of the sample from the cervical lymph node biopsy revealed reactive lymphoid hyperplasia. Int J Dermatol ; It is caused or triggered by exposure to ultraviolet radiation, cold and drugs and develops gradually.

Lúpus eritematoso sistêmico bolhoso: diagnóstico diferencial com dermatite herpetiforme

golhoso The patient remained stable during 1 year of follow-up. Systemic lupus erythemato sus in patients diagnosed with treatment-resistant acne.

Am J Clin Dermatol. The differential diagnosis of comedogenic discoid CLE are: Gluten intolerance was also investigated, and the results were negative for IgA anti-gliadin, IgG anti-gliadin, anti-endomysium and antitissue transglutaminase antibodies.

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J Am Acad Dermatol. Luiz Carlos Takita 1 Dr. It interferes with the chemotaxis of neutrophils and the release of lysosomal enzyme by polymorphonuclear cells. Autoimmune blistering skin diseases. Approved by the Advisory Board and accepted for publication on Support Center Support Center.


Chronic lupus erythematosus presenting as acneiform lesions. Open in a separate window. Rio Branco, 39 Favre-Racouchot disease, also known as ‘cutaneous nodular elastoidosis with cysts and comedones’ is characterized by volumous open, black comedones, located on the sun damaged skin of the elderly.

Guilherme Canho Bittner 1 Dr. The case described here illustrates the typical signs and symptoms of bullous systemic lupus erythematosus and draws attention to the need for clinical and histopathological differential diagnosis with dermatitis herpetiformis.

Direct immunofluorescence reveals a linear or granular deposition of IgG, IgA and C3 in the basement membrane zone.

They can be partially restored with concomitant use of IU of vitamin E once a day. Childhood-onset bullous systemic lupus erythematosus. Received May 22; Accepted Sep Footnotes Conflict of interest: Echocardiogram showed a minimal increase in pericardial fluid and chest radiography showed a mild, bilateral pleural effusion.

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